Men’s Second Round Odds 2025-26: Spreads and Lines for All 16 Matches

We’re diving into the second round of basketball’s biggest tournament. Let’s check out the odds for the Men’s NCAA Tournament Round of 16 on DraftKings Sportsbook starting March 21. This page may contain affiliate links to legal sports betting partners. If you register or place a bet, FOX Sports may be compensated. Learn more about sports betting on FOX Sports. SATURDAY, MARCH 21 No. 12 High Point vs. No. 4 Arkansas Spread: Arkansas -11.5Moneyline: Arkansas -700, HPU +500O/U: 168.5 No. 11 Texas vs. No. 3 Gonzaga Spread: Gonzaga -6.5Moneyline: Gonzaga -250, Texas +205O/U: 147.5 No. 11 VCU vs No. 3 Illinois Spread: Illinois -11.5Moneyline: Illinois -550, VCU +410O/U: 151.5 No. 10 Texas A&M vs. No. 2 Houston Spread: Houston -10.5Moneyline: Houston -500, TA&M +380O/U: 142.5 No. 9 Saint Louis vs. No. 1 Michigan Spread: Michigan -12.5Moneyline: Michigan -900, SLU +600O/U: 161.5 No. 9 TCU vs. No. 1 Duke Spread: Duke -11.5Moneyline: Duke -800, TCU +550O/U: 139.5 No. 6 Louisville vs. No. 3 Michigan State Spread: MSU -4.5Moneyline: MSU -192, Louisville +160O/U: 151.5 No. 5 Vanderbilt vs. No. 4 Nebraska Spread: Vandy -1.5Moneyline: Vandy -125, Nebraska +105O/U: 146.5 SUNDAY, MARCH 22 No. 9 Utah State vs. No. 1 Arizona Spread: Arizona -11.5Moneyline: Arizona -800, Utah State +550O/U: 156.5 No. 9 Iowa vs. No. 1 Florida Spread: Florida -10.5Moneyline: Florida -600, Iowa +440O/U: 145.5 No. 7 Kentucky vs. No. 2 Iowa State Spread: Iowa State -4.5Moneyline: Iowa State -218, Kentucky +180O/U: 145.5 No. 7 UCLA vs. No. 2 UConn Spread: UConn -4.5Moneyline: UConn -205, UCLA +170O/U: 139.5 No. 6 Tennessee vs. No. 3 Virginia Spread: Tennessee -1.5Moneyline: Tennessee -118, Virginia -102O/U: 137.5 No. 5 St. John’s vs. No. 4 Kansas Spread: St. John’s -2.5Moneyline: St. John’s -148, Kansas +124O/U: 143.5 No. 5 Texas Tech vs. No. 4 Alabama Spread: Alabama -1.5Moneyline: Alabama -112, Texas Tech -108O/U: 165.5