Men’s Sweet 16 Odds 2025-26: Spread, Lines, What You Need to Know for All 8 Matches

Sixteen teams remain and eight matches are on deck. Let’s take a look at the NCAA Men’s Tournament Sweet 16 odds on DraftKings Sportsbook as of March 23, as well as what to know about each game. This page may contain affiliate links to legal sports betting partners. If you register or place a bet, FOX Sports may be compensated. Learn more about sports betting on FOX Sports. THURSDAY, MARCH 26 No. 4 Arkansas vs. No. 1 Arizona Spread: Arizona -8.5Moneyline: Arizona -395, Arkansas +310O/U: 166.5 What you need to know: Things haven’t been very easy for Arizona so far in this tournament. Yes, he broke and covered against 16-seed Long Island in the first round (92-58), but the second round was a bit tougher, as he outlasted 9-seed Utah State (78-66), covering by half a point. Still, the Wildcats are nearly 10-point favorites over a Razorbacks team that beat 13-seed Hawai’i in the first round (97-78) and beat 12-seed High Point in the second round (94-88). Arizona has been favored by less than 10 11 times this season, covering six of those games. No. 3 Illinois vs. No. 2 Houston Spread: Houston -2.5Moneyline: Houston -148, Illinois +124O/U: 139.5 What you need to know: Houston won its first-round game and its second-round game by exactly 31 points, against 15th-seed Idaho (78-47) and 10th-seed Texas A&M (88-57), respectively. The Cougars did it on defense, not allowing either opponent to score 30 points in a half in the first two rounds. Illinois defeated 14th-seeded Penn by 35 (105-70) in the first round and 11th-seeded VCU by 21 (76-55) in the second round. Both teams covered in their two tournament victories. No. 11 Texas vs. No. 2 Purdue Spread: Purdue -7.5Moneyline: Purdue -360, Texas +285O/U: 148.5 What you need to know: Purdue looks like the preseason title favorite that it was. The Boilermakers beat Michigan in the Big Ten title game, then beat Queens U in the first round (104-71) and Miami FL in the second round (79-69). Now, they’re favored over a Texas team that cruised past fellow 11th-seeded NC State in the First Four (68-66) before upsetting 6th-seeded BYU in the first round (79-71) and 3rd-seeded Gonzaga in the second round (74-68). Both teams covered each of their matches in the tournament. No. 9 Iowa vs. No. 4 Nebraska Spread: Nebraska -2.5Moneyline: Nebraska -148, Iowa +124O/U: 134.5 What you need to know: The first major upset of the tournament belonged to the Hawkeyes, who beat Florida, seeded 1 and defending champion, in the round of 16 (73-72). Wow. Iowa was a 10.5-point underdog in that one, having covered its first round with No. 8 seed Clemson (67-61). Nebraska covered its two games in the tournament, beating 13th-seeded Troy (76-47) and 5th-seeded Vanderbilt (74-72). Now the Hawkeyes and Cornhuskers will have a Big Ten rematch, after splitting the season series. Iowa won at home, 57-52, and Nebraska won at home, 84-75. FRIDAY, MARCH 27 No. 5 St. John’s vs. No. 1 Duke Spread: Duke -6.5 Moneyline: Duke -310, St. John’s +250O/U: 142.5 What you need to know: Duke has been favored in nine straight games, but has only covered four of the last six. In the round of 16, the Blue Devils scared themselves against Siena, seeded 16, by winning by six after being favored by 28.5 (71-65). In the round of 16, Duke got back on track, beating 9th-seeded TCU by 23 after entering as a 12.5-point favorite (81-58). As for St. John’s, it had covered six in a row – including its first-round win over 12-seed UNI (79-53) – before beating 4-seed Kansas by two in the second round (67-65) as a 3.5-point favorite. No. 4 Alabama vs. No. 1 Michigan Spread: Michigan -10.5Moneyline: Michigan -600, Alabama +440O/U: 175.5 What you need to know: Michigan won its first two games of the tournament by 20+, beating 16th-seeded Howard (101-80) and then 9th-seeded Saint Louis (95-72). However, he only covered the round of 16 and the Wolverines failed to cover six of their last seven games, in which they were all favored. The Crimson Tide steamrolled 13-seed Hofstra in the first round (90-70), then kept that momentum going against 5-seed Texas Tech in the second round (90-65). Alabama covered both games. No. 3 Michigan State vs. No. 2 UConn Spread: UConn -1.5Moneyline: UConn -115, MSU -105O/U: 137.5 What you need to know: UConn has won two of the last three championships, and it’s still here to make it three of four. The Huskies beat 15th-seeded Furman in the first round (82-71), but failed to cover, then covered against 7th-seeded UCLA in the second round (73-57). The Spartans knocked off 14th-seeded North Dakota State in the first round (92-67), then beat 6th-seeded Louisville in the second round (77-69). They covered both games. This one is in selection territory. No. 6 Tennessee vs. No. 2 Iowa State Spread: ISU -4.5Moneyline: ISU -198, Tennessee +164O/U: 137.5 What you need to know: Iowa State hasn’t faced much resistance so far in the tournament, beating 15th-seeded Tennessee State in the first round (108-74) and 7th-seeded Kentucky in the second round (82-63). Tennessee defeated Miami OH, seeded 11, in the round of 16 (78-56), before beating Virginia, seeded 3, in the round of 16. Both teams covered each of their first two games of the tournament. ISU has covered its last six games, five of which have been wins, all by 19 or more. Its only loss was to Arizona by two.