2026 NFL Odds: Giants open as underdogs against Cowboys in John Harbaugh’s debut

It’s officially NFL schedule release week. On Thursday, fans will finally know the full 18-week regular season schedule for every NFL team. However, the league has already started revealing some of the biggest matchups of the season ahead of the official release. The NFL previously announced that the San Francisco 49ers and Los Angeles Rams would meet in the league’s historic first-ever game in Australia to open their season. Additionally, the Baltimore Ravens and Dallas Cowboys are scheduled to face off in the NFL’s inaugural game in Rio de Janeiro in week three. This page may contain affiliate links to legal sports betting partners. If you register or place a bet, FOX Sports may be compensated. Learn more about sports betting on FOX Sports. Now, the league has officially revealed another marquee matchup: the Week 1 Sunday Night Football opener between two of the NFL’s most historic franchises, the Cowboys and the New York Giants. With the announcement now official, the game’s opening odds have already been released by DraftKings Sportsbook on May 11. Cowboys @ Giants (Week 1) Spread Cowboys -1.5: -115 (bet $10 to win $18.70 total) Giants +1.5: -105 (bet $10 to win $19.52 total) Moneyline Cowboys: -130 (bet $10 to win $17.69 total)Giants: +110 (bet $10 to win $21 total) Total O 47.5: -115 (bet $10 to win $18.70 total)U 47.5: -105 (bet $10 to win $19.52 total) The spotlight in this game immediately turns to John Harbaugh, who will make his prime-time Giants debut against one of the franchise’s biggest rivals. The longtime Ravens head coach was hired by New York in January after spending 18 seasons in Baltimore and now takes the helm of a Giants team looking to turn the corner after two straight last-place finishes in the NFC East and just seven wins overall over the past two seasons. Meanwhile, Dallas enters 2026 with its own major changes. After allowing an NFL-worst 30.1 points per game last season while also ranking last in pass defense and 30th in total defense, the Cowboys completely revamped that side of the ball by hiring former Philadelphia Eagles assistant Christian Parker as defensive coordinator. Dallas also made several key additions this offseason, including using its first-round pick on star safety Caleb Downs. Both teams are expected to make significant progress in 2026, with the Cowboys’ win total set at 9.5 and the Giants’ at 7.5. This game will mark the eighth time since 2012 that the NFC East rivals have met in a season opener. The Cowboys dominated these games, winning six of the final seven Week 1 games against the Giants. The question now is whether John Harbaugh can change that narrative and begin his tenure with the Giants with a declared victory. Punters will have all summer to think about it.