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Nick Reiner Became Murderous After Switching Schizoaffective Medications

Ivan Mehta by Ivan Mehta
January 8, 2026
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Nick Reiner Became Murderous After Switching Schizoaffective Medications

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Nick Reiner Evidence that schizoaffective drugs made him murderous

Published January 8, 2026 at 1:00 a.m. PST

nick rob michele reiner getty comp

Nick Reinerthe nervous breakdown in the weeks preceding the murders of his parents, Fly And Michele Reineris directly linked to a life-changing decision by doctors to change the medications he was taking for his mental illness… sources with direct knowledge tell TMZ.

reiner-doc-clip-kal--v2-01-07-2025

TMZ Studios

TMZ has a new documentary — “TMZ Investigates: The Reiner Murders: What Really Happened” – airing Friday at 8 p.m. ET on FOX. We explain in the doc that Nick was diagnosed with schizoaffective disorder around 2020… an illness that manifests with symptoms of schizophrenia – including delusions, hallucinations and disorganized thinking – and symptoms of mood disorders – including mania and severe depression.

michele rob nick reiner under getty swipe

Our sources say that a month before the murders, Nick was stable on his medication for schizoaffective disorder… we’re told the medication was working very well. For some reason, his doctors decided to change his treatment. Our sources wouldn’t say why the doctors made this decision…only that we would be shocked to learn the reason, which we’re told makes no sense.

We’re told the change in medications sent Nick into a spiral. He became agitated, erratic and increasingly dangerous. Our sources say Rob and Michele were alarmed by what they saw, but didn’t know what to do.

nick-reiner-hochman-presser-kal-01-07-2026

TMZ.com

Our sources say that at the time of the murders, Nick was completely out of touch with reality. We’re told doctors didn’t attempt to place Nick on psychiatric hold while they tried to adjust medications and stabilize him.

This, we are told, may be the heart of Nick’s defense: the doctors sent Nick on a path that drove him legally insane. Under California law…a defendant does not need to demonstrate that he did not know the difference between right and wrong to use the insanity defense…only that he did not understand the nature and quality of his act.

010726_tmz_rob_reiner_promo_kal

TMZ.com

“TMZ Investigates the Reiner Murders: What Really Happened”… airs Friday night on FOX at 8 p.m. ET.

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Ivan Mehta

Ivan Mehta

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